Application to Estimate Haplotypes for Multiallelic Present-Absent Loci
نویسنده
چکیده
The article presents an algorithm and an application to estimate haplotype frequencies from genotype data for unrelated individuals. Presented approach can handle loci with multiple alleles as well as silent (null) alleles. The mathematical model and an expanded Expectation-Maximization algorithm is described. The computer program, called NullHap, available freely at http://staff.elka.pw.edu.pl/ ~rnowak2/nullhap implements presented ideas. Comparison with known software to estimate haplotypes: Arlequin, PHASE and Haplo-IHP proves the advantage presented method.
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تاریخ انتشار 2008